Researchers
have identified a gene that appears to curb caffeine consumption, a finding
which may explain why some people tend to drink fewer cups of coffee. The study
by researchers found that people with a DNA variation in a gene called PDSS2
tend to drink fewer cups of coffee. The findings suggest that the gene reduces
the ability of cells to breakdown caffeine, causing it to stay in the body for
longer. This means that a person would not need to consume as much coffee to
get the same caffeine hit. The findings add to previous studies that have
identified genes linked to coffee habits and shed new light on the biological
mechanisms of caffeine metabolism. Researchers looked at genetic information
from 370 people living in a village in south Italy and 843 people from six
villages in north-east Italy. Each of the participants was asked to complete a
survey that included a question about how many cups of coffee they drank each
day. Researchers found that people with the DNA variation in coffee than people
without the variation. Researchers replicated the study in a group of 1,721
people from the Netherlands. The results were similar but the effect of the gene
on the number of cups of coffee consumed was slightly lower.
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