Scientists claim to have developed
tiny, star-shaped molecules which may effectively wipe out deadly bacteria that
can no longer be killed by current antibiotics. The study holds promise for a
new treatment method against antibiotic resistant bacteria, commonly known as
superbugs. The star-shaped structures are short chains of proteins called ‘peptide
polymers’. Researchers said that currently the only treatment for infections
caused by bacteria is antibiotics. However, over time bacteria mutate to
protect themselves against antibiotics, making treatment no longer effective. These
mutated bacteria are known as ‘superbugs’. It is estimated that the rise of
superbugs will cause up to 10 million deaths a year by 2050. In addition, there
have only been one or two new antibiotics developed in the last 30 years.
Recently, the team created a
star-shaped peptide polymer that was effective at killing Gram-negative
bacteria – a major class of bacteria known to be highly prone to antibiotic
resistance – while being non-toxic to the body. Tests undertaken on red blood
cells showed that the star-shaped polymer dosage rate would beed to be
increased by a factor of greater than 100 to become toxic. The star-shaped
peptide polymer is alos effective in killing superbugs when tested in animal
models. Superbugs showed no signs of resistance against these peptide polymers.
The discovered that their star-shaped peptide polymers can kill bacteria with
multiple pathways, unlike most antibiotics which kill with a single pathway.
Researchers believe that this
accounts for the superior performance of the star-shaped peptide polymers over
antibiotics. One of these pathways includes ‘ripping apart’ the bacteria cell
wall. While more research is needed, researchers believe that their discovery
is the beginning of unlocking a new treatment for antibiotic-resistant
pathogens.