Scientists launched a global
initiative on 14 October to map out and describe every cell in the human body
in a vast atlas that could transform researchers understanding of human
development and disease. The atlas, which is likely to take more than a decade
to complete, aims to chart the types and properties of all human cells across
all tissues and organs and build a reference map of the healthy human body. Cells
are fundamental to understanding the biology of all health and disease, but
scientists cannot yet say how many we have, how many different types there are,
or how they differ from one organ to another. The human cell atlas initiative
is the beginning of a new era of cellular understanding. Researchers will
discover new cell types, find how cells change across time during development
and disease, and gain a better understanding of biology. The project is
currently led by a team from the Broad Institute of the Massachusetts Institute
of Technology (MIT) and Harvard in the United States, the Sanger Institute and
Wellcome Trust in Britain. The plan is for research teams and funder worldwide
to collaborate. By making the atlas – essentially a vast database of cellular
detail – freely available to scientists the world over, the scientists hope to
transform research into human development and the progression of diseases such
as asthma, Alzheimer’s and cancer. The human body is made of trillions of cells
– the fundamental units of life – which divide, grow and take on distinct
functions in embryo, eventually leading to different cell types such as skin
cells, neutrons or fat cells. Until recently, scientific knowledge of cells has
been limited to what can be found out by looking at them under microscopes, or
by genetically analyzing clumps of hundreds or thousands of cells and finding
their average properties. But technological advances in field known as single
cell genomics means researchers can now separate individual cells from
different tissues and organs, analyze their properties and measure and describe
which molecules are produced in each.
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