Scientists
have unveiled the inner workings of a group of proteins that help to switch critical
genes on and off during blood-cell production, a finding that could lead to the
development of new and improved cancer drugs. One of the proteins involved is
linked to breast cancer, which is the most common form of cancer for women and
kills more than half a million women globally each year. Existing breast cancer
treatments do not target this protein specifically. The study could help
explain how existing breast cancer drugs work inside human cells. There are
treatments for breast cancer which are in use today that are effective but we
still do not know how they work. This research shines a light on an important set
of proteins that could be targeted by these drugs and superior treatments yet
to be developed. The research seeks to understand the mechanisms for gene regulation,
particularly in relation to disease such as cancer and blood disorders. Researchers
described how a special group of proteins form into enzymes that turn genes on
and off to produce essential elements such as blood cells and stem cells. The ongoing
research will help scientists advance their knowledge of how genes are
regulated. It also may lead to development of new and improved cancer drugs.
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