A nano-carrier
engineered to be small enough to get past the blood-brain barrier could be
targeted to deliver a chemotherapeutic drug more efficiently to tumour cells on
the brain. Researcher said “I was surprised by how efficiently and well it
worked once we got the nano-carrier to those cells.” Initial results were
promising. It potentially points the way to a new treatment option for patients
with conditions such as glioblastoma multiforme (GBM). The brain tumour has a
significant overall mortality, in part due to its location, difficulty of
surgical treatment and the inability to get drugs through the blood-brain
barrier. This led researchers to nanotechnology. They took what they know about
the cancer’s biology and of platelet-derived growth factor (PDGF). They engineered
a micelle that is a phospholipid nano-carrier, a bit of fat globule, deliver a
concentrated close of the chemotherapy drug temozolomide (TMZ) to the GBM
tumour cells.
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